To evaluate the feasibility of treating prehypertension with an angiotension receptor blocker candesartan cilexetil

Prehypertension is considered a precursor of stage 1 hypertension and a predictor of excessive cardiovascular risk. The trial of preventing hypertension [TROPHY] was an investigator-initiated study to examine whether early treatment of prehypertension, defined for this study as systolic blood pressure of 130 to 139 mmHg and diastolic pressure blood pressure of 89 mmHg or lower and systolic pressure of 139 mmHg or lower, might prevent or delay the development of subsequent incident hypertension. The primary objective of the present study was to determine whether in patients with prehypertension six months of treatment with an angiotensin II, type I receptor antagonist [at a dose of 8mg once a day] reduces the incidence of hypertension in borderline patients

Role of leukotriene receptor antagonist in acute severe attack of bronchial asthma in comparison with conventional therapy

This study was designed to determine the role of leukotriene receptor antagonist in acute severe attack of bronchial asthma in comparison with conventional therapy. Asthma is a chronic inflammatory lung disease in both the developed and developing countries. Asthmatic patients are at risk of worsening of disease characterized by an increased breathlessness, cough, chest discomfort and wheezing and decreased in expiratory airflow rate. Leukotrienes are lipid mediators synthesized from arachidonic acid, and element of which are potent chemo attractants. These chemical mediators are involved in the pathogenesis of asthma. Study results reveled the effectiveness of leukotriene receptor antagonist in preventing many types of aggravated asthmatic responses. Oral administration of leukotriene receptor antagonist in acute asthmatic patients improves airway function. Once-daily treatment with 10 mg of montelukast, as compared with conventional therapy, provided significant protection against severe broncho-constriction. Study also shows that there was no worsening of the disease. Parameters strongly confirmed the role of leukotriene receptor antagonist when in addition added with steroid therapy in the treatment of acute asthma, there were a smooth improvement was noticed